Female Cancer Risks

Male Cancer Risks

Associated Syndrome

Cancer Risk Table

To age 2015%0.3% Other – including non-Melanoma Skin, Lung, Leukemia, Lymphoma, Esophageal, Neuroblastoma, Thyroid, and KidneyTo age 80Elevated RiskNA

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Overall cancer risk (male) To age 5 14%-22% 0.1%
  To age 20 25%-33% 0.4%
  To age 50 60%-67% 3.4%
  To age 70 79%-95% 20.3%
Overall cancer risk (female) To age 5 3%-22%% 0.1%
  To age 20 15%-20% 0.3%
  To age 50 73%-92% 5.4%
  To age 70 82%-100% 19.2%
Overall cancer risk (male and female) Risk for second primary cancer within 10 years of a first cancer diagnosis 50% NA
Female Breast To age 70 85% with strong tendency towards very young ages of diagnosis – the large majority of cases occurring before age 45 7.1%
Other – including Adrenocortical Carcinoma, Choroid Plexus Carcinoma, Soft Tissue Sarcoma, Bone Sarcoma, and Brain To age 80 Greatly increased risk, with a strong tendency towards young ages of diagnosis – sometimes in childhood. NA
Colorectal To age 80 Elevated risk, with a strong tendency towards young ages of diagnosis – the median age of diagnosis is estimated to be 41. 3.0%
Other – including non-Melanoma Skin, Lung, Leukemia, Lymphoma, Esophageal, Neuroblastoma, Thyroid, and Kidney To age 80 Elevated Risk NA
Gastric To age 80 Elevated risk, with a tendency towards young ages of diagnosis. 0.6%
Ovarian To age 80 Possibly Elevated 1.0%
Pancreatic To age 80 Possibly Elevated 1%
Prostate To age 80 Possibly Elevated 10.9%
Endometrial To age 80 Possibly Elevated 2.4%
Melanoma To age 80 Possibly Elevated 1.6%

Medical Management

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Overall Cancer Risk Provide education about the signs and symptoms of cancer As needed As needed
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. 18 years NA
  Clinical breast examination 20 years, or at the age of the earliest diagnosis in the family if under age 20. Every 6 to 12 months
  Breast MRI with contrast and/or Mammography with consideration of tomosynthesis Age 20 for MRI. Age 30 for both MRI and mammography. Annually
  Consider risk-reducing mastectomy. Individualized NA
Other including Adrenocortical Carcinoma, Sarcomas, Brain tumors, Leukemia, Lymphoma, and other cancers, especially those for which there is a past diagnosis in the family. Comprehensive physical and neurological examination From birth Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
  Whole body MRI, including brain From birth Annually
  Abdominal and pelvic ultrasound From birth Every 3 to 4 months (from birth to age 18) and annually from age 18
Colorectal Colonoscopy 25 years, or 5 years younger than the earliest colorectal cancer in the family, whichever comes first Every 2 to 5 years
Other including Gastric, Ovarian, Endometrial, Prostate and Pancreatic cancer. Comprehensive physical and neurological examination From birth Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
  Whole body MRI, including brain From birth Annually
Gastric Upper Endoscopy 25 years, or individualized to a younger age based on family history Every 2 to 5 years
Melanoma Skin examination 18 years Annually

Unique Challenges and Issues