Female Cancer Risks

Male Cancer Risks

Associated Syndrome

TP53 Summary Cancer Risk Table

CANCER TYPE GENETIC CANCER RISK
Female Breast High Risk
Colorectal Elevated Risk
Endometrial Elevated Risk
Gastric Elevated Risk
Melanoma Elevated Risk
Ovarian Elevated Risk
Pancreatic Elevated Risk
Prostate Elevated Risk
Other High Risk

Cancer Risk Table

To age 2015%0.3% Other – including non-Melanoma Skin, Lung, Leukemia, Lymphoma, Esophageal, Neuroblastoma, Thyroid, and KidneyTo age 80Elevated RiskNA

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Overall cancer risk (male) To age 5 14%-22% 0.1%
  To age 20 25%-33% 0.4%
  To age 50 60%-67% 3.4%
  To age 70 79%-95% 20.3%
Overall cancer risk (female) To age 5 3%-22%% 0.1%
  To age 20 15%-20% 0.3%
  To age 50 73%-92% 5.4%
  To age 70 82%-100% 19.2%
Overall cancer risk (male and female) Risk for second primary cancer within 10 years of a first cancer diagnosis 50% NA
Female Breast To age 70 85% with strong tendency towards very young ages of diagnosis – the large majority of cases occurring before age 45 7.1%
Other – including Adrenocortical Carcinoma, Choroid Plexus Carcinoma, Soft Tissue Sarcoma, Bone Sarcoma, and Brain To age 80 Greatly increased risk, with a strong tendency towards young ages of diagnosis – sometimes in childhood. NA
Colorectal To age 80 Elevated risk, with a strong tendency towards young ages of diagnosis – the median age of diagnosis is estimated to be 41. 3.0%
Other – including non-Melanoma Skin, Lung, Leukemia, Lymphoma, Esophageal, Neuroblastoma, Thyroid, and Kidney To age 80 Elevated Risk NA
Gastric To age 80 Elevated risk, with a tendency towards young ages of diagnosis. 0.6%
Ovarian To age 80 Possibly Elevated 1.0%
Pancreatic To age 80 Possibly Elevated 1%
Prostate To age 80 Possibly Elevated 10.9%
Endometrial To age 80 Possibly Elevated 2.4%
Melanoma To age 80 Possibly Elevated 1.6%

Medical Management

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Overall Cancer Risk Provide education about the signs and symptoms of cancer As needed As needed
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. 18 years NA
  Clinical breast examination 20 years, or at the age of the earliest diagnosis in the family if under age 20. Every 6 to 12 months
  Breast MRI with contrast and/or Mammography with consideration of tomosynthesis Age 20 for MRI. Age 30 for both MRI and mammography. Annually
  Consider risk-reducing mastectomy. Individualized NA
Other including Adrenocortical Carcinoma, Sarcomas, Brain tumors, Leukemia, Lymphoma, and other cancers, especially those for which there is a past diagnosis in the family. Comprehensive physical and neurological examination From birth Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
  Whole body MRI, including brain From birth Annually
  Abdominal and pelvic ultrasound From birth Every 3 to 4 months (from birth to age 18) and annually from age 18
Colorectal Colonoscopy 25 years, or 5 years younger than the earliest colorectal cancer in the family, whichever comes first Every 2 to 5 years
Other including Gastric, Ovarian, Endometrial, Prostate and Pancreatic cancer. Comprehensive physical and neurological examination From birth Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
  Whole body MRI, including brain From birth Annually
Gastric Upper Endoscopy 25 years, or individualized to a younger age based on family history Every 2 to 5 years
Melanoma Skin examination 18 years Annually

Unique Challenges and Issues