Cancer Risks

Associated Syndrome

STK11 gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Colorectal To age 70 39% 1.8%
Pancreatic To age 70 11%-36% 0.5%
Female Breast To age 70 45%-50% 7.1%
Gastric To age 70 29% 0.4%
Small Bowel To age 70 13% 0.1%
Ovarian To age 70 18%-21% 0.7%
Endometrial To age 70 9% 1.7%
Cervical To age 70 10% 0.5%
Testicular To age 70 Elevated risk 0.4%
Lung To age 70 15%-17% 2.2%

STK11 Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Colorectal Colonoscopy Baseline at age 8, or earlier if symptomatic, with follow-up as needed. Every 2 to 3 years after age 18
Pancreatic Magnetic resonance cholangiopancreatography (MRCP) with contrast or endoscopic ultrasound (EUS). 30 to 35 years, or 10 years younger than the earliest age of diagnosis in the family Every 1 to 2 years
Female Breast Breast awareness – Women should be familiar with their breasts to promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. 18 years NA
  Clinical breast examination 25 years Every 6 months
  Mammography and breast MRI with contrast 25 years Annually
Gastric Upper endoscopy Baseline at age 8 , or earlier if symptomatic, with follow up as needed Every 2 to 3 years after age 18
Small Bowel Small bowel visualization with CT or MRI enterography or video capsule endoscopy. Baseline at 8 years, or ealier is symptomatic, with follow up as needed, but no later than age 18 Every 2 to 3 years after age 18
Ovarian Physical exam, monitor for precocious puberty Childhood Annually
  Pelvic examination 18 to 25 years Annually
  Consider transvaginal ultrasound 25 years Annually
Endometrial Pelvic examination 18 to 25 years Annually
  Consider transvaginal ultrasound. 25 years Annually
Cervical Pap smear 18 to 25 years Annually
Testicular Physical and testicular examination and observation for feminizing changes Childhood Annually
Lung Provide education about symptoms and smoking cessation. As needed As needed

Unique Challenges and Issues