Hereditary Cancer Syndromes > POLD1, POLE, MSH3

POLD1, POLE, and MSH3 Biallelic Summary Cancer Risk Table

CANCER GENETIC CANCER RISK
Colorectal Elevated Risk

POLD1, POLE, and MSH3 Biallelic Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Colorectal To age 80 Elevated Risk 3.0%

POLD1, POLE, and MSH3 Biallelic Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN

FREQUENCY

Unless otherwise indicated by findings.

Colorectal Colonoscopy 25 to 30 years Every 2 to 3 years
  Colorectal surgical evaluation and counseling Based on cancer diagnosis and/or polyp number, size and histology NA

MSH3 Monoallelic gene

Carrier Status for MSH3-associated Cancer Risk 

  • Individuals with a mutation in only one copy of the MSH3 gene (a monoallelic mutation) are not believed to have any increased risk for cancer over people in the general population.