Cancer Risks

Associated Syndrome

NBN gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Female Breast To age 80 Up to 30% 10.2%
Prostate To age 80 Increased risk 10.9%

NBN Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. Individualized NA
  Clinical encounter, including clinical breast exam, ongoing risk assessment and risk-reduction counseling  When genetic risk is identified Every 6 to 12 months
  Mammography with consideration of tomosynthesis  and consideration of breast MRI with contrast Age 40, or modified to a younger age based on the family history of breast cancer Annually
  Consider additional risk-reduction strategies.  Individualized NA
Prostate Currently there are no specific medical management guidelines for prostate cancer risk in mutation carriers. However, the possibility of an increased risk for prostate cancer can be incorporated into the risk and benefit discussion about offering screening with digital rectal examination (DRE) and Prostate Specific Antigen (PSA). 45 years, or younger Individualized

Slavic Founder Mutation

Slavic Countries

Unique Challenge and Issues