Cancer Risks

Cancer Risk

Associated Syndrome

Associated Syndrome

Associated Syndrome

Summary Cancer Risk Table

Two Copies

CANCER  GENETIC CANCER RISK
Colorectal High Risk 
Other High Risk 

One Copy

CANCER  GENETIC CANCER RISK 
Colorectal Elevated Risk

Gene Cancer Risk Table

Two Copies

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Colorectal To Age 80 43% – 100% 3.0%
Small Bowel  To Age 80 5% 0.2%

One Copy

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Colorectal To Age 80 3.4% – 10% 3.0%

Medical Management

Two Copies

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Colorectal Colonoscopy 25 to 30 years Every 1 to 2 years
  Colorectal surgical evaluation and counseling. Based on cancer diagnosis and/or polyp number, size and histology NA
Small Bowel Consider upper endoscopy, including complete visualization of the ampulla of Vater 30 to 35 years Every 4 years

One Copy

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Colorectal Currently there are no medical management guidelines for colorectal cancer risk in patients with a single MUTYH mutation unless colorectal cancer has been diagnosed in a first-degree relative. N/A N/A

Unique Challenges