NTHL1 Biallelic gene

Associated Syndrome Name: NTHL1-associated Cancer Risk

Summary Cancer Risk Table

 

CANCER  GENETIC CANCER RISK 
Colorectal Elevated Risk
Female Breast Elevated Risk

Gene Cancer Risk Table

 

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Colorectal To Age 80 Elevated risk 3.0%
Female Breast To Age 80 Elevated risk 10.2%

Cancer Risk Management Table

 

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Colorectal Colonoscopy 25 to 30 years Every 2 to 3 years
  Colorectal surgical evaluation and counseling. Based on cancer diagnosis and/or polyp number, size and histology N/A
Female Breast Currently there are no specific medical management guidelines for female breast cancer risk in biallelic mutation carriers. However, the possibility of an increased risk for breast cancer warrants consideration of individualized breast cancer risk-reduction strategies, such as the modification of standard population screening recommendations by starting screening at younger ages and/or performing screenings at greater frequency. N/A N/A