Cancer Risks

CHEK2 gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION
Female Breast To age 80 23%-48% 10.2%
  Second primary within 10 years of first breast cancer diagnosis Up to 29% 4.0%
Male Breast To age 80 0.4%-1% 0.1%
Colorectal To age 80 Possibly elevated risk 3.0%

CHEK2 Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. Individualized NA
  Clinical encounter, including clinical breast exam, ongoing risk assessment and risk reduction counseling When genetic risk is identified Every 6 to 12 months
  Mammography with consideration of tomosynthesis and consideration of breast MRI with contrast Age 40, or modified to a younger age based on the family history of breast cancer Annually
  Consider additional risk-reduction strategies. Individualized NA
Male Breast Currently there are no specific medical management guidelines for breast cancer risk in mutation carriers. However, the increase in risk warrants consideration of options for male breast cancer screening, such as patient breast awareness education, clinical breast examinations. Individualized NA
Colorectal Colonoscopy 40 years, or 10 years younger than the age of diagnosis for any first-degree relative with colorectal cancer  Every 5 years

Unique Challenges and Issues