Hereditary Cancer Syndromes > CDKN2A (p16INK4a), CDKN2A (p14ARF), CDK4

Cancer Risks

Cancer Risks

Associated Syndrome

Summary Cancer Risk, Gene, and Medical Management Tables

CDKN2A (p16INK4a)

Summary Cancer Risk Table

CANCER  GENETIC CANCER RISK 
Melanoma High Risk
Pancreatic High Risk

Gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK

RISK FOR GENERAL POPULATION

Melanoma To age 50 14%-50% 0.3%
  To age 80 28%-76% 1.6%
Pancreatic To age 75 Up to 17% 0.7%

Medical Management 

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Melanoma Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen. Infancy Ongoing
  Whole-body skin examinations conducted by the patient or family member. 10 years Monthly
  Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison. 10 years Every 6 to 12 months
Pancreatic Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols. Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family Annually
  Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight. Individualized Individualized

 

CDKN2A (p14ARF)

Summary Cancer Risk Table

CANCER  GENETIC CANCER RISK 
Melanoma High Risk
Pancreatic Elevated Risk

Gene Cancer Risk Table 

CANCER TYPE AGE RANGE CANCER RISK

RISK FOR GENERAL POPULATION

Melanoma To age 50 14%-50% 0.3%
  To age 80 28%-76% 1.6%
Pancreatic To age 75 Elevated Risk  0.7%

Medical Management 

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Melanoma Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen. Infancy Ongoing
  Whole-body skin examinations conducted by the patient or family member. 10 years Monthly
  Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison. 10 years Every 6 to 12 months
Pancreatic Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols. Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family Annually
  Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight. Individualized Individualized

 

CDK4

Medical Management 

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Melanoma Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen. Infancy Ongoing
  Whole-body skin examinations conducted by the patient or family member. 10 years Monthly
  Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison. 10 years Every 6 to 12 months
Pancreatic Currently there are no specific medical management guidelines for pancreatic cancer risk in mutation carriers. NA NA

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