Cancer Risks

Associated Syndrome

CHD1 gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Gastric (male) To age 80 67%-70% 0.6%
Gastric (female) To age 80 56%-83% 0.6%
Female Breast To age 50 10% 1.9%
  To age 80 39%-52% 10.2%
Colorectal To age 80 Possibly elevated risk 3.0%

CDH1 Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Gastric Gastrectomy 18 to 40 years, or individualized to a younger age if a relative was diagnosed under age 25 NA
  Baseline endoscopy prior to gastrectomy. Endoscopies with targeted biopsies may be appropriate for patients delaying or declining gastrectomy. Individualized Every 6 to 12 months
  Consider testing and treating for Helicobacter pylori infection if present. Individualized NA
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. 18 years NA
  Clinical breast examination 25 years Every 6 
  Mammography with consideration of tomosynthesis and consideration of breast MRI with contrast 30 to 35 years  Annually
Colorectal Consider colonoscopy for patients with a family history of colorectal cancer. Individualized Individualized

Unique Challenges and Issues