Cancer Risks

Associated Syndrome

CDH1 Summary Cancer Risk Table

CANCER  GENETIC CANCER RISK 
Female Breast High Risk
Gastric High Risk
Colorectal Elevated Risk

CHD1 gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Gastric (male) To age 80 67%-70% 0.6%
Gastric (female) To age 80 56%-83% 0.6%
Female Breast To age 50 10% 1.9%
  To age 80 39%-52% 10.2%
Colorectal To age 80 Possibly elevated risk 3.0%

CDH1 Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Gastric Gastrectomy 18 to 40 years, or individualized to a younger age if a relative was diagnosed under age 25 NA
  Baseline endoscopy prior to gastrectomy. Endoscopies with targeted biopsies may be appropriate for patients delaying or declining gastrectomy. Individualized Every 6 to 12 months
  Consider testing and treating for Helicobacter pylori infection if present. Individualized NA
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. 18 years NA
  Clinical breast examination 25 years Every 6 months
  Mammography with consideration of tomosynthesis and consideration of breast MRI with contrast 30 to 35 years Annually
Colorectal Consider colonoscopy for patients with a family history of colorectal cancer. Individualized Individualized

Unique Challenges and Issues