Cancer Risks

Associated Syndromes

ATM gene Cancer Risk Table

CANCER TYPE AGE RANGE CANCER RISK RISK FOR GENERAL POPULATION *
Female Breast To age 50 Up to 9% 1.9%
  To age 80 17%-52% 10.2%
Pancreatic To age 80 Elevated risk 1%

ATM Cancer Risk Management Table

CANCER TYPE PROCEDURE AGE TO BEGIN FREQUENCY
Female Breast Breast awareness – Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness. Individualized NA
  Clinical encounter, including clinical breast exam, ongoing risk assessment and risk reduction counseling When genetic risk is identified Every 6 to 12 months
  Mammography with consideration of tomosynthesis and consideration of breast MRI with contrast Age 40, or modified to a younger age based on the family history of breast cancer Annually
  Consider additional risk-reduction strategies. Individualized NA
Pancreatic For patients with a family history of pancreatic cancer, consider available options for pancreatic cancer screening, including the possibility of endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in the screening for pancreatic cancer, preferably within research protocols. Age 50, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family Annually
  Provide education about smoking cessation to reduce pancreatic cancer risk Individualized Individualized
For Patients With A Cancer Diagnosis For patients with a gene mutation and a diagnosis of cancer, targeted therapies may be available as a treatment option for certain tumor types (e.g., platinum chemotherapy, PARP-inhibitors) NA NA

Unique Challenges and Issues